South Central Missouri is defined by rugged Ozark terrain, clear rivers, caves, and vast forested areas. This region is a favorite for outdoor enthusiasts, offering floating, hiking, camping, fishing, and scenic exploration. Communities here often serve as gateways to conservation areas and national forests.
The region maintains a strong connection to nature and traditional Missouri culture. Visitors experience small-town hospitality, historic routes, and easy access to some of the state’s most unspoiled landscapes.
| City | Population (2020) | County |
|---|---|---|
| Ava | 2,894 | Douglas County |
| Camdenton | 3,960 | Camden County |
| Eldon | 4,416 | Miller County |
| Lake Ozark | 2,077 | Camden County, Miller County |
| Lebanon | 15,013 | Laclede County |
| Mountain Grove | 4,313 | Wright County (mostly), Texas County (part) |
| Osage Beach | 4,637 | Camden County (mostly), Miller County (part) |
| Rolla | 19,943 | Phelps County |
| Saint James | 3,935 | Phelps County |
| Saint Robert | 5,192 | Pulaski County |
| Salem | 4,608 | Dent County |
| Waynesville | 5,406 | Pulaski County |
| West Plains | 12,184 | Howell County |