East Central Missouri connects the St. Louis metropolitan area with rural landscapes and historic Route 66 communities. The region features rolling hills, forests, vineyards, and river valleys, offering a diverse mix of urban access and natural beauty. Transportation corridors make this area an important link between eastern and central Missouri.
Visitors enjoy historic towns, outdoor recreation areas, wineries, caves, and classic roadside attractions. East Central Missouri is ideal for travelers who want variety combining city access with countryside experiences and scenic drives.
| City | Population (2020) | County |
|---|---|---|
| Affton | 20,417 | St. Louis County |
| Arnold | 20,858 | Jefferson County |
| Ballwin | 31,103 | St. Louis County |
| Bellefontaine Neighbors | 10,860 | St. Louis County |
| Bridgeton | 11,635 | St. Louis County |
| Chesterfield | 49,999 | St. Louis County |
| Clayton | 17,461 | St. Louis County |
| Concord | 17,668 | St. Louis County |
| Cottleville | 6,495 | St. Charles County |
| Crestwood | 12,566 | St. Louis County |
| Creve Coeur | 18,067 | St. Louis County |
| De Soto | 6,549 | Jefferson County |
| Des Peres | 8,989 | St. Louis County |
| Eureka | 11,369 | St. Louis County |
| Ferguson | 18,527 | St. Louis County |
| Festus | 12,434 | Jefferson County |
| Florissant | 52,533 | St. Louis County |
| Harvester | N/A | St. Charles County |
| Hazelwood | 25,657 | St. Louis County |
| Jennings | 13,761 | St. Louis County |
| Kirkwood | 29,175 | St. Louis County |
| Lake Saint Louis | 16,707 | St. Charles County |
| Lemay | 17,117 | St. Louis County |
| Manchester | 18,094 | St. Louis County |
| Maryland Heights | 27,472 | St. Louis County |
| Mehlville | 28,955 | St. Louis County |
| Oakville | 36,301 | St. Louis County |
| O’Fallon | 91,316 | St. Charles County |
| Overland | 15,623 | St. Louis County |
| Pacific | 7,002 | Franklin County, St. Louis County |
| Saint Clair | 4,791 | Franklin County |
| Saint Paul | 3,005 | St. Charles County |
| Saint Peters | 57,732 | St. Charles County |
| Saint-Charles | 70,493 | St. Charles County |
| Sainte Genevieve | 4,999 | Ste. Genevieve County |
| St. Louis | 301,578 | City of St. Louis (independent) |
| Sullivan | 6,906 | Franklin County |
| Town and Country | 11,371 | St. Louis County |
| Troy | 12,180 | Lincoln County |
| Union | 11,620 | Franklin County |
| University City | 34,581 | St. Louis County |
| Washington | 14,500 | Franklin County |
| Warrenton | 8,429 | Warren County |
| Webster Groves | 23,230 | St. Louis County |
| Weldon Spring | 5,326 | St. Charles County |
| Wentzville | 44,372 | St. Charles County |
| Wildwood | 35,417 | St. Louis County |